“PURPOSE: To report refractive, topographic, aberrometric, GSK3326595 and tomographic outcomes 24 months after corneal cross-linking (CXL) in patients up to 18 years of age with progressive keratoconus.\n\nDESIGN: Prospective, interventional case series.\n\nMETHODS: Forty eyes underwent riboflavin-ultraviolet A-induced CXL. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), sphere and cylinder, topography, aberrometry, tomography, and endothelial cell counts were evaluated at baseline and at 1,
3, 6, 12, and 24 months.\n\nRESULTS: Mean logarithm of the minimum angle of resolution baseline UCVA and BSCVA were 0.79 +/- 0.21 and 0.39 +/- 0.10, respectively. Mean UCVA and BSCVA at 2 years were 0.58 +/- 0.18 and 0.20 +/- 0.09, respectively. The improvement in UCVA and BSCVA was significant throughout the postoperative follow-up (P < .05). Mean spherical equivalent refraction showed a significant decrease of 1.57 diopters (D) at 24 months (P = .02). Mean baseline simulated keratometry was 46.32 D in the flattest meridian and 51.48 D in the steepest meridian; at 2 years, the values were 45.30 D (P = .04) and 50.21 D (P = .07), respectively. For a 3-mm pupil, there was a significant reduction (P < .05) in whole
eye (total), corneal, higher-order, and astigmatic wavefront aberrations at 24 months. A significant difference (P < .05) in total coma and total spherical aberration Selleckchem VS-6063 2 years after CXL also was observed. Mean baseline pupil center pachymetry decreased significantly
(P = .04) at 6 Elafibranor Metabolism inhibitor months, but recovered by 12 months and remained stable thereafter through the 2-year follow-up. Endothelial cell counts did not change significantly (P = .32).\n\nCONCLUSIONS: CXL improved UCVA and BSCVA in the study patients, most likely by significantly reducing corneal asymmetry and corneal as well as total wavefront aberrations. (Am J Ophthalmol 2012;154:520-526. (C) 2012 by Elsevier Inc. All rights reserved.)”
“Background: Casts are well known components of the urinary sediment. For most casts, the clinical associations are known and demonstrated, while for waxy casts they are totally unknown.\n\nMethods: Prospective study for the search and count of waxy casts in the urinary sediment of patients with different types of glomerular diseases.\n\nResults: Waxy casts were found in 39 out of 287 patients (13.6%), mostly in low number (1 to 9 out of 100 casts evaluated/sample). They were frequent in postinfectious glomerulonephritis and renal amyloidosis (5/9 patients, 44.5%, p = 0.02 for each condition), while they were rare in membranous nephropathy (4/67 patients, 6.0%, 0.04) and absent in focal segmental glomerulosderosis (0/23 patients, p = 0.05). Waxy casts were associated significantly with higher serum creatinine levels (p < 0.