The Bi nanoclusters were fabricated by thermal evaporation at EX 527 cost room temperature on transmission electron microscope grids coated with an ultrathin carbon film, followed by thermal and femtosecond laser annealing. The annealed sample had an average cluster

size of similar to 14 nm along the minor axis and similar to 16 nm along the major axis. The Debye temperature of the annealed nanoclusters was found to be 53 +/- 6 K along the [012] direction and 86 +/- 9 K along the [110] direction. At T=464 +/- 6 K, the diffraction intensity started to deviate from Debye-Waller behavior due to increased lattice anharmonicity. The onset of the melting of the Bi nanoclusters was T similar to 500 +/- 6 K, as measured by the reduction of the nanocluster size through the formation of a liquid shell detected by the width of the diffraction rings. The thermal expansion coefficient of the Bi (012) and (110) planes is positive up to similar to 499 +/- 11 K. However, the expansion coefficient of the Bi (012) planes showed a transition from a positive to a negative value that occurs over the temperature range

Luminespib ic50 T(c) similar to 499 +/- 11 K to 511 +/- 8 K. For the Bi (110) planes, the thermal expansion coefficient is positive up to their melting point, which is 525 +/- 6 K. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3565028]“
“This study compares the effects of two different types of nanosized fillers (silica and montmorillonite) at three different weight fractions as well their mixtures on the thermomechanical properties of polylactide (PLA). The role of aggregation and interphase

was investigated in terms of several experimental Selleckchem JIB 04 techniques, including scanning electron microscopy, wide-angle X-ray scattering (WAXS), thermogravimetric analysis, differential scanning calorimetry, dynamic mechanical analysis (DMA), and tensile measurements. The experimental results clearly suggest that silica and montmorillonite have different reinforcing and toughening effects on PLA, while the combination of the two different nanofillers has a detrimental effect on the tensile properties of the material. Four micromechanics models describing the Young’s modulus of the nanocomposites were used to study the different matrix-nanofiller interactions. The best fit of the experimental results was obtained with a model that assumes the presence of an interphase surrounding each nanoparticle. The increase of the nanofiller content above a certain amount was not accompanied by a corresponding increase of the interphase, because the total nanofiller surface area was counterbalanced by the creation of aggregates. It is postulated that the aggregation effect acts antagonistically to the interphase effect. (C) 2011 Wiley Periodicals, Inc.

The tumor cells of the squamous component were negative for vimentin and SMA; however, many of the tumor cells of the polyhedral/basal component exhibited vimentin. In addition, expression of SMA was confirmed in some tumor cells of the acinar and basal components. LY333531 Based on the microscopic and immunohistochemical characterizations, the tumor was

diagnosed to be adenosquamous carcinoma that originated from the mammary gland with rapid growth, and the tumor cells demonstrated epithelial-mesenchymal transition-like changes. (DOI: 10.1293/tox.25.265; J Toxicol Pathol 2012; 25: 265-271)”
“The rheological and chemorheological behavior of a new biomass-based polyfurfuryl alcohol (FA) resin aimed to be used as a matrix in composite materials is studied in this work. The viscosity dependence on the shear rate and temperature of the resin is studied under steady and oscillatory conditions. The FA resin exhibits a Newtonian flow behavior within the shear rate range tested. The dependence of the viscosity of the uncured resin on temperature is measured and modeled. The flow activation energy, as calculated

by the Arrhenius model, is 63.3 kJ mol(-1). The chemorheological study of the curing process showed that the flow activation energy of the resin is increased when the amount of catalyst is increased. Furthermore, the curing parameters of the FA resin using three amounts of catalyst of 2, 4, and 6% (w/w), are obtained by the Arrhenius model. The curing activation energy is found to be about 96 kJ mol(-1) and with no dependence on the amount of catalyst. However, a significant difference Galardin research buy of the logarithm of the pre-exponential curing parameter is found. This parameter increases from 28.9 to 30.7 when the amount

of catalyst is increased from 2 to 6% (w/w). Based on the established values of the Arrhenius model parameters, predictions are made for the evolution of viscosity of the resin during isothermal curing with ATM Kinase Inhibitor DNA Damage inhibitor different temperatures, and different amounts of catalyst. This is of great importance in the design of the curing processes of the FA resin during development and improvement of composite manufacturing processes. (C) 2013 Elsevier B.V. All rights reserved.”
“Objective: The purpose of this study was to assess the presence and effectiveness of existing systems of prioritization for Cochrane review topics and to explore methods of improving those systems.

Study Design and Setting: We surveyed groups of Cochrane review authors and recorded any evidence of their use of priority-setting processes or policies. To evaluate the effectiveness of the policies we encountered, we assessed them using two frameworks from the literature: “”Accountability for Reasonableness”" (1) and Sibbald’s 2009 framework (2) for successful priority setting. We then held two workshops with the subject groups to discuss our findings and their implications.

The AL method on 2DE more closely approximated LVEF by CMR (r = 0.73, p = 0.0003) than BiS method (r = 0.53, p = 0.02). AL method was not limited by geometric assumptions, as AL method on CMR closely approximated Simpson’s method on CMR (r = 0.90, p < 0.0001) despite median left-ventricular diastolic eccentricity index of 1.24. AL method on 2DE was

primarily limited by short-axis area measurement rather than foreshortening of the ventricle. In conclusion, in adults with rTOF, AL method on 2DE moderately approximates LVEF by CMR, even in the context of altered left-ventricular geometry. Although the AL method may be the most appropriate 2DE method in this population, significant limitations remain for LVEF assessment by 2DE, AS1842856 Metabolism inhibitor and strategies to optimize image position and border detection are essential.”
“Polychlorinated

biphenyls (PCBs) are a class of persistent organic pollutants with myriad biological effects, including carcinogenicity. We present data showing gender-specific genotoxicity in Fischer 344 transgenic BigBlue rodents exposed to 4-chlorobiphenyl (PCB3), a hydroxylated www.selleckchem.com/products/ABT-263.html metabolite, and the positive control 3-methylcholanthrene (3-MC) where female rats are more resistant to the genotoxic effects of the test compounds compared to their male counterparts. This difference is further highlighted through our examination

of gene expression, organ-specific weight changes, and tissue morphology. The purpose of the present study was to explore the complex and learn more multifaceted issues of lower molecular weight PCBs as initiators of carcinogenesis, by examining the mutagenicity of PCB3, a hydroxylated metabolite (4′-OH-PCB3). and 3-methylcholanthrene (3-MC, positive control) in a transgenic rodent model. Previous findings indicated that PCB3 is mutagenic in the liver of male BigBlue transgenic rats under identical exposure conditions. We expected that female rats would be equally, if not more sensitive than male rats, since a 2-year carcinogenesis bioassay with Sprague-Dawley rats and commercial PCB mixtures reported much higher liver cancer rates in female than in male rats. The current study, however, revealed a similar trend in the mutation frequencies across all four treatment groups in females as reported previously in males, but increased variability among animals within each group and a lower overall effect, led to non significant differences in mutation frequencies.

Thirty-four patients (67 %) answered the questionnaire after a mean follow-up interval of 4.3 years (10-87 months). Among these patients, 36 % reported an improved course of disease after PUVA therapy with reduced frequency and/or intensity of the skin rash, and 29 % of patients reported continued complete clearance. 79 % of our patients reported a long-term reduction in the use of topical corticosteroids during the follow-up period (mean: AZD8931 mouse 4.3 years). In addition, 67 % of patients reported a lasting improvement in quality of

life.

Conclusions: These data show that bath PUVA may have a long-term, beneficial influence on the course of disease in a majority of patients with recalcitrant chronic palmoplantar dermatoses.”
“This article highlights the latest findings regarding the cognitive-behavioral syndromes of neglect and anosognosia for hemiplegia that occur following right hemisphere stroke. We review papers published in the past 2 years pertaining to neurophysiology, assessment, and intervention for these two syndromes.”
“N,N-Diglycidylaniline was reacted with aniline (yielding polymer EP-1) and the newly

synthesized chromophore 4-(phenylazo)aniline (yielding polymer EP-2). The curing kinetics of these two epoxy resin systems was studied in dynamic experiments by means of differential scanning calorimetry. Kinetic parameters such as the activation energy and frequency factor were estimated with the Ozawa method [E(O) and A(O), respectively], the Kissinger method [E(K) and A(K), respectively], and the selleck chemical modified Avrami method [E(A) and A(A),

respectively]. The activation energy and frequency factor of EP-1 were much lower than those of EP-2 estimated with the Ozawa, Kissinger, and Avrami methods. The activation energy and frequency factor for EP-1 determined with the Ozawa method [E(O) = 55.8 kJ/mol, A(O) = 10 x 10(3) 1/s] and the Avrami method [E(A) = 56.4 kJ/mol, A(A) = 9.2 x 10(3) 1/s] were find more higher than those determined with the Kissinger method [E(K) = 51.0 kJ/mol, A(K) = 2 x 10(3) 1/s]. In the case of EP-2, the kinetic parameters calculated with the Ozawa model [E(O) = 140.4 kJ/mol, A(O) = 12.3 x 10(13) 1/s] and the Kissinger model [E(K) = 139.9 kJ/mol, A(K) = 10.9 x 10(13) 1/s] were higher than those calculated with the Avrami model [E(A) = 130.4 kJ/mol, A(A) = 7.9 x 10(12) 1/s]. The obtained polymers were characterized with Fourier transform infrared, (1)H-NMR, differential scanning calorimetry, and ultraviolet-visible spectroscopy. The polymers exhibited low glass-transition temperatures in the range of 57-79 degrees C and good solubility in common organic solvents. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 113: 3596-3604, 2009″
“Background: Monotherapy with TNF-alpha inhibitors does not always produce a sufficient response in psoriasis patients.

A small number of patients with Takayasu arteritis and IgG4-related aortitis have also been successfully treated with the B-cell depleting agent rituximab, and some patients with refractory Takayasu arteritis have responded to the immunomodulator CHIR-99021 mw leflunomide.

Summary

The possibility of biologic therapy in large vessel vasculitis has emerged. At this time, better delineation of the immunopathogenic

mechanisms of this spectrum of diseases and prospective randomized clinical trials are required to move the field forward and decrease the cumulative glucocorticoid toxicity seen in these disorders.”
“Background

Although screw breakage or loosening are rarely encountered, they were reported to occur after instability of the internal fixation.

Methods

A man with a history of traumatic pelvic fracture 6 months ago presented to our clinic SCH 900776 solubility dmso with inability to void. An anterior urethral meatotomy was made and a calcified but intact screw was removed from the urethra.

Conclusions

Screw migration with urological manifestations are extremely rare and usually include bladder migration with a subsequent voiding of the screw. We present a case in which internal urethrotomy for posterior urethral stricture caused erosion of a bone screw into the urethra which was subsequently removed by anterior meatotomy.”
“Purpose of review

Cryoglobulinemia vasculitis (CryoVas) is a small-vessel

vasculitis associated with chronic infections [in particular hepatitis Selleckchem GSK621 C virus, (HCV)], autoimmune disorders and B-cell lymphoproliferative disorders. The most recent studies on its diagnosis, prognosis and therapeutic management are reviewed here.

Recent findings

Large series of patients with HCV-positive and negative mixed CryoVas and patients with monoclonal type I CryoVas have described the presentation and the prognosis of patients with CryoVas in the era

of HCV screening. European experts in the field of CryoVas developed new classification criteria for its diagnosis. Finally, French, Italian and North American clinical studies demonstrated that rituximab-based regimens were highly effective in comparison with corticosteroids alone or other immunosuppressive agents-based therapy. However, rituximab seems to be associated with an increased risk of severe infections in a subset of patients.

Summary

Recent studies identified prognostic factors of survival and demonstrated that rituximab is highly effective but remains associated with severe infections in a subset of patients. These results could support individual therapeutic stratification according to the clinical pattern and associated comorbidities.”
“Introduction

Carcinoid heart disease is a rare condition in adults. Its diagnosis can be easily missed in a patient presenting to a primary care setting. We revised the advantages of using coronary multidetector computed tomography (MDCT) and cardiac magnetic resonance imaging (MRI) in diagnosing this condition.

There was also no significant difference between patients and spouses in the subcategories of QoL with the exception of the perceived effect on work life, which was greater in patients than spouses

(P = 0.041).

Conclusions: AF has a similar perceived impact on the QoL of spouses and patients. QoL improvement strategies for patients with AF should take spouses into account. (PACE 2011; 34: 804-809)”
“Information processing in the human brain arises from both interactions between adjacent areas and from Citarinostat concentration distant projections that form distributed brain systems. Here we map interactions across different spatial scales by estimating the degree of intrinsic functional connectivity for the local (<= 14 mm) neighborhood directly surrounding brain regions as contrasted with distant (>14 Prexasertib ic50 mm) interactions. The balance between local and distant functional interactions measured at rest forms a map that separates sensorimotor cortices from heteromodal association areas and further identifies regions that possess both high local and distant cortical-cortical interactions. Map estimates of network measures demonstrate that high local connectivity is most often associated with a high clustering

coefficient, long path length, and low physical cost. Task performance changed the balance between local and distant functional coupling in a subset of regions, particularly, increasing local functional coupling in regions engaged by the task. The observed

properties suggest that the brain has evolved a balance Tariquidar datasheet that optimizes information-processing efficiency across different classes of specialized areas as well as mechanisms to modulate coupling in support of dynamically changing processing demands. We discuss the implications of these observations and applications of the present method for exploring normal and atypical brain function.”
“A modified Landau-Ginzburg-Devonshire theory is developed to investigate the “”diameter-temperature”" phase diagram and the ferroelectric behaviors of BaTiO3 nanowires. Four phases, such as the Cubic phase, the Tetragonallike phase, the Orthorhombic phase, and the Monoclinic phase, are obtained. The ferroelectric phase transition temperatures are all depressed as the diameter decreases. A temperature-dependent critical diameter below which the polarization disappears is 0.8 nm at 0 K. Moreover, the magnitude and the direction of the polarization are strongly dependent on the diameter as well as the dielectric behaviors. Therefore, it can generate a specific direction of the polarization by controlling the diameter of the nanowires which may optimize the physical properties. (C) 2011 American Institute of Physics. [doi:10.1063/1.3559810]“
“Background: Atrial fibrillation (AF) is a prevalent condition associated with adverse outcomes that need to be addressed by clinicians.

in poultry litter and serum antibody titers against coccidia in broiler chickens raised on the used litters. The programs included in ovo vaccination and various medications with

either chemicals, ionophores, or both. In general, serum samples from these chickens showed anticoccidial antibody titers when tested at days 7 and 14 post hatch with the peak response at day 43. Serum anticoccidial titers were highest in birds fed a non-medicated diet compared with those vaccinated or fed medicated diets. Total number of Eimeria oocysts and the composition of Eimeria spp. present in the litter samples from different treatment groups varied depending on the type of anticoccidial program. Oocyst counts in general ranged from 3.7 x 10(3) to 7.0 x 10(4) per g of litter. Importantly, both morphological and Autophagy Compound Library purchase molecular typing studies revealed four major predominant Eimeria spp., E. acervulina, E. maxima, E. praecox, and E. tenella in the litter samples. Collectively, Ganetespib solubility dmso these results indicate that the field anticoccidial programs influenced the type and abundance of Eimeria spp. present in the litter samples and also modulated host immune response to Eimeria. Published by Elsevier Ltd.”
“Thin poly(4-vinylpyridine) films terminally anchored onto nonporous inorganic oxide

substrates were synthesized by aqueous phase reverse atom transfer radical graft polymerization (ATRGP). Surface initiators were immobilized on the inorganic substrate surface by chemically attaching glycidoxytrimethoxy silane onto the substrates followed by conversion of the glycidoxy silane into azobis silane by a reaction with 4,4′-azobis(4-cyanovaleric acid). Reverse ATRGP of 4-vinylpyridine onto the active surface azo sites was carried out in a 1-methyl-2-pyrrolidone/water solvent mixture using CuCl(2)/2,2′-bipyridine as the catalyst-ligand complex with initial monomer concentration [M](0) = 2.32M at 90 degrees C. Controlled radical polymerization was achieved at catalyst to initiator molar ratios of 2 : 1 and 3 : 1, with a catalyst to ligand molar ratio of 1 : 2. Controlled polymerization was indicated by a

first-order rate of polymerization kinetics, with respect to monomer conversion at the surface and in solution, the linear MGCD0103 increase of the P4VP graft yield with time, and a low polydispersity index (PDI < 1.40). The highest graft yield of 8 mg/m(2) was achieved at a 3 : 1 catalyst to initiator molar ratio which corresponded to a number-average molecular weight of 11,500 g/mol, surface density of 0.69 mol/m(2), and a polydispersity index of 1.28. AFM surface analysis of the grafted polymer films, prepared by reverse ATRGP of 4VP, revealed a decrease in the RMS surface roughness (R(RMS)) = 1.04 nm) and feature size (feature diameter = 20-45 nm), relative to uncontrolled free radical graft polymerization (R(RMS)) = 1.

measurements: TST induration was measured at 48, 72 and 96 h by two nurses

by palpation and a ruler, palpation and a Vernier caliper, ballpoint pen and a ruler or ballpoint pen and a Vernier caliper. TST differences were assessed using mixed-effects analysis. We also assessed the rate of false-positive/-negative results and the variability of the TST measurements. RESULTS: We performed 767 TST measurements. The adjusted mean TST size was larger with PPD-S than with PPD-RT23 (12.8 vs. 10.8 mm, P < 0.001), and at 72 h than at 48 h and 96 h (13.4 vs. 11.8 vs. 10.1 mm, P < 0.05). The smallest number of false results was observed with PPD-S, the ballpoint pen-ruler and at 72 h; palpation+ruler had the least variability at 72 h. CONCLUSIONS: The TST should ideally be AZD8186 clinical trial performed with PPD-S and measured at 72 h with the ballpoint pen+ruler or palpation+ruler GS-9973 Angiogenesis inhibitor methods.”
“We report the first described case of minimal deviation adenocarcinoma

of the uterine cervix in the setting of a female renal cadaveric transplant recipient.

A retrospective review of this clinical case was performed.

This rare cancer represents only about 1% of all cervical adenocarcinoma.”
“We describe the prevalence and risk factors for PAD in Asian Malays with diabetes. A population-based study of 3,280 (78.7% response) Malay persons aged 40-80 years in Singapore was conducted.ABI was measured in all participants with a history of diabetes (N=634). PAD was defined to be present if ABI <= 0.9. All participants had standardised interviews, clinical examinations and laboratory investigation for risk factor assessment.The crude ATM inhibitor prevalence of PAD was 10.4% (95% CI: 8.35-13.0%). After age standardisation to the 2000 Singapore Census population, the prevalence was 5% (95% CI: 3.8-8.6). In multivariate analyses, the presence of PAD was associated with older age (OR 1.05; 95% CI: 1.01-1.09, per year increase), female gender (OR 4.18; 95% CI: 1.67-10.43), cigarette smoking (OR 2.55; 95% CI: 1.05-6.20), higher systolic blood pressure (OR 1.28; 95% CI: 1.13-1.45),

a history of myocardial infarction (OR 3.69; 95% CI: 1.79-7.61) and stroke (OR 3.06 95% CI: 1.25-7.50). In this Asian Malay population with diabetes, we found a high prevalence of PAD.The major risk factors for PAD among persons with diabetes are similar to studies in Caucasian populations, suggesting that strategies aimed at controlling the modifiable factors may reduce the prevalence of PAD in Asian populations.”
“SETTING: Few data on drag-resistant (DR) tuberculosis (TB) in children are available in Thailand. objectives: To evaluate the rate, clinical features and risk of DR-TB in children. DESIGN: Observational prospective study conducted in children diagnosed with TB at a tertiary care centre in Bangkok. RESULTS: Of 230 children diagnosed with TB, the median age was 6.

Three different concentrations of sevoflurane were administered through a face mask under spontaneous respiration to maintain anesthesia. A mixture of sevoflurane, oxygen, and air of 5 l center dot min-1 was given through a face mask for anesthesia. Group 1 (n = 32) received 1.5% sevoflurane, Group 2 (n = 32) 1.25% sevoflurane, and Group 3 (n = 32) 1.0% sevoflurane. Recovery time, removal from the MRI room, postanesthesia care unit discharge data, and

complications were also recorded. Heart rate, mean arterial pressure (MAP), peripheral oxygen saturation (SpO(2)), respiration rate, and anesthesia adequacy were recorded every 5 min from the time of induction until completion of the MRI.

Results:

All selleck chemical three groups were similar in demographic and hemodynamic respiratory features. MRI was successfully performed in 96.6% of all patients without additional intervention. Sevoflurane concentrations were increased for a short time in one patient in Group 1 and in two patients in Group 3. Oxygen flow was increased in one patient in Group 1 and in one patient

in Group 2 as SpO(2) was lower than 95%. The mean time to eye opening (from discontinuation of sevoflurane to eye opening) was 155.8 +/- 50.0 s in Group 1, 89.5 +/- 16.0 s in Group 2, and 53.5 +/- 10.0 s in Group 3; differences between the groups were statistically significant (P = 0.001). Airways were not PXD101 in vivo used on any of the patients, and none vomited or required endotracheal intubation

or laryngeal mask anesthesia.

Conclusions:

We believe that the administration of sevoflurane at a concentration of 1% via a face mask under spontaneous respiration GDC 941 may provide light anesthesia without complications to induce an unarousable sleep for children during MRI.”
“The effect of thermal vibrations on modal frequencies of flexural vibration for a scanning thermal microscope (SThM) cantilever probe has been evaluated using the Timoshenko beam model, including the effects of rotary inertia and shear deformation, and an analytical expression for the frequencies of vibration modes has been obtained. According to this analysis, the thermal vibration effect makes the probe stiffer and leads to an increasing frequency in the nanomachining process. This phenomenon may result in a rough machined surface of the materials. The resonant frequency of vibration modes decreases as the length-to-thickness ratio of the probe increases. The mode shape decreases with increasing the operating temperature in SThM machining. In addition, the results based on Euler beam and Timoshenko beam models are compared. It can be found that the Timoshenko beam model is able to predict the frequencies of flexural vibration of the higher modes for the SThM cantilever probe nanomachining. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.

Methods: This secondary analysis uses data from a randomized controlled trial in diabetic PD patients with high or high-average peritoneal transport using icodextrin-based (ICO group, n = 30) or glucose-based (GLU group, n = 29) solutions for the long dwell. All patients underwent 24-hour electrocardiographic Holter monitoring at baseline, and at 6 and 12 months of follow-up.

Results: We observed no significant differences between the groups in most of the variables analyzed, although values were, in general, below reference values. In the ICO group, total power and both low-and high-frequency power in normalized units increased,

but the percentage of RR intervals with variation of more than 50 ms declined over time; in the GLU group, all those values declined. Plasma catecholamine levels were higher at baseline and declined Selleck TH-302 over time.

Conclusions: These results indicate

a partial recovery of sympathetic activity in the ICO group, probably because of better extracellular fluid control and lower exposure to glucose with the use of icodextrin-based dialysis solutions.”
“Background/aims: Treatment of chronic HCV infection has become a priority in HIV+ patients, given the faster progression to end-stage liver disease. The primary endpoint of this study was to evaluate and compare antiviral efficacy of Peginterferon alpha 2a plus ribavirin in HIV-HCV co-infected and HCV mono-infected Topoisomerase inhibitor patients, and to examine whether 6 months of therapy would have the same efficacy in HIV patients with favourable

genotypes 2 and 3 as in mono-infected patients, to minimise HCV-therapy-related toxicities. Secondary endpoints were to evaluate predictors of sustained virological response (SVR) and frequency of side-effects.

Methods: selleck screening library Patients with genotypes 1 and 4 were treated for 48 weeks with Pegasys(R) 180 mu g/week plus Copegus(R) 1000-1200 mg/day according to body weight; patients with genotypes 2 and 3 for 24 weeks with Pegasys(R) 180 mu g/week plus Copegus(R) 800 mg/day.

Results: 132 patients were enrolled in the study: 85 HCV mono-infected (38: genotypes 1 and 4; 47: genotypes 2 and 3), 47 HIV-HCV co-infected patients (23: genotypes 1 and 4; 24: genotypes 2 and 3). In an intention-to-treat analysis, SVR for genotypes 1 and 4 was observed in 58% of HCV mono-infected and in 13% of HIV-HCV co-infected patients (P = 0.001). For genotypes 2 and 3, SVR was observed in 70% of HCV mono-infected and in 67% of HIV-HCV co-infected patients (P = 0.973). Undetectable HCV-RNA at week 4 had a positive predictive value for SVR for mono-infected patients with genotypes 1 and 4 of 0.78 (95% CI: 0.54-0.93) and of 0.81 (95% CI: 0.64-0.92) for genotypes 2 and 3.