Tables 1 and 2 show the characteristics of the patients and the controls before and after drug administration. The effects of chlorpromazine on the studied parameters before and after drug administration were present in Table 3. A non-significant differences were found between body weight, BMI, and waist circumferences. A significant reduction of serum glucose concentration

was obtained. A significant elevation of total cholesterol and triglycerides and a significant reduction of HDL cholesterol were noted. The effects of olanzapine on the studied parameters before and after drug administration were shown in Table 4. A non-significant differences Selleckchem BI-6727 were found between body weight, BMI, and waist circumferences. see more A significant elevation of serum glucose concentration was obtained. A significant elevation of total cholesterol and triglycerides and a significant reduction of HDL cholesterol were noted. Table 5 shows the correlation between BMI of the patients and serum glucose

concentration and lipid profile. A significant correlation was found between BMI and these parameters. The present study showed that chlorpromazine or olanzapine have some effects on serum glucose concentration and lipid profile. Serum glucose concentration was significantly reduced on therapy with chlorpromazine while it increased with olanzapine. Lipid parameters were elevated with both drugs. Both drugs have no significant effects on body weight, BMI and waist circumferences. The effects of olanzapine on serum glucose concentration and lipid profile have been studied previously. Kaushal et al11 reported in a study comparing the effects of olanzapine and risperidone on serum glucose and lipid

profile that olanzapine significantly increases the serum levels of glucose and lipid profile. In another study7 comparing the effects of olanzapine with typical antipsychotics that Olanzapine-treated patients had significant glucose elevations at all time points, in comparison with patients receiving typical antipsychotics as well as untreated healthy control subjects. Haupt and Newcomer12 Reported that Dyslipidemia is a feature of type 2 diabetes, and antipsychotics such as clozapine and olanzapine have also been associated with hypertriglyceridemia, with because agents such as haloperidol, risperidone, and ziprasidone associated with reductions in plasma triglycerides. In a study published in year 2000, hyperinsulinemia was established in 71% of patients with schizophrenia or related types of psychoses who were on olanzapine therapy for 6 months on average. Hyperglycemia was also confirmed in three of these patients, and indicated the onset of diabetes.13 Regarding the effects of olanzapine on serum lipids. Koro et al14 demonstrated a significant increase in the levels of both triglycerides and cholesterol of olanzapine-treated patients.