Case series of this invasive disease have been reported in both immunocompromised and immunocompetent patients.5, 6 Infections caused by Entomophthorales

include both conidiobolomycosis and basidiobolomycosis, with the latter being the most common cause of the disease.3 It seems that Entomophthoramycosis is age related. Conidiobolomycosis is uncommon in children, but 88% of basidiobolomycosis cases occur in patients younger than 20 years.7 Historically, they have been known to cause skin and soft-tissue infections in otherwise healthy individuals Inhibitors,research,lifescience,medical in tropical areas of Africa, South America, and Asia. Visceral involvement is extremely unusual and so far has been reported Inhibitors,research,lifescience,medical only in association with Basidiobolus. B. ranarum was first isolated in 1955 from decaying plants in the United States, and was subsequently found in soil and vegetation throughout the world. B. ranarum may also be present as a commensal in the intestinal tracts of frogs, toads, turtles, chameleons, horses, and dogs. The first human case of infection caused by B. ranarum was one of subcutaneous mycosis, Inhibitors,research,lifescience,medical reported in 1956 in Indonesia, and other cases subsequently occurred in India,

Africa, and South America. In 1978 the first culture-proven case of invasive basidiobolomycosis of the maxillary sinus was reported in the United States, and reports of visceral involvement followed afterwards.1 Basidiobolomycosis Inhibitors,research,lifescience,medical can involve any region of gastrointestinal tract including stomach, duodenum, pancreas, liver, terminal ileum, cecum, Cell Cycle inhibitor ascending colon, transverse colon, rectum, and biliary system. The site of involvement in the present case was descending colon.8 Yousef describe six cases of gastrointestinal

basidiobolomycosis of stomach and intestine. Specimens were characterized by marked mural thickening with fibrosis, Inhibitors,research,lifescience,medical prominent tissue eosinophil infiltration and palisading granulomatous inflammation around pale fungal hyphae. There was colonic perforation in two cases. According to their report, Basidiobolus ranarum hyphae (associated with spore-like spherules in four cases) were identified within tissue sections; the irregularly branched, thin-walled, occasionally septated hyphae were typically surrounded by a thick eosinophilic cuff (Splendore-Hoeppli phenomenon).2 others Geramizadeh et al reported three cases with complaints of constipation, rectal bleeding, abdominal distension and intestinal obstruction. Other symptoms reported in the literature include fever, sweats, diarrhea, memory loss, rectal pain, constipation, anorexia, fatigue, mucus discharge, nausea and vomiting.3 Owing to vague complaints, the disease is generally confused with gastrointestinal malignancies, inflammatory bowel diseases, amebiasis or dysentry. Due to rarity of the disease, diagnosis is often made with some delay and after tissue resection and microscopic examination.