When challenging a child sensitized to peanut, clinicians should be prepared and equipped to handle any reaction in all cases.”
“The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D human breast tumor cells (66% inhibition at 3 mu M). Compound 1 also suppressed hypoxic induction of HIF-1 target genes (VEGF, GLUT-1) at the mRNA level, and displayed tumor cell line-selective time-dependent inhibition of cell viability/proliferation. Mechanistic studies selleck compound revealed that 1 selectively suppressed mitochondrial respiration at complex I (IC(50) 3 mu M). Thyrsiferol represents a prototypical, structurally
unique electron transport chain inhibitor. The apparent rotenone-like activity may contribute to the observed cytotoxicity of 1 and play an important role in Laurencia chemical defense. click here (C) 2010 Phytochemical
Society of Europe. Published by Elsevier B. V. All rights reserved.”
“Objective: Informatics-based knowledge translation interventions have the potential to address clinical practice and patient care, but evidence shows that they can fail, have the potential to be ineffective, function poorly, and result in medical or technology-induced errors if rushed to become an integral part of health care systems and practices. In an attempt to meet these challenges and advance the science of developing knowledge translation interventions, the objective of this study was to apply two theoretical frameworks (the Knowledge-to-Action and the Medical Research Council frameworks for complex interventions) in the development of an osteoporosis clinical decision support tool.
Study Design and Setting: Descriptive analysis of how the Knowledge-to-Action and Medical Research Council frameworks can be applied in the development of an osteoporosis tool.
Results: An osteoporosis tool was developed using a seven-phase process by collapsing the “”action”" steps of the Knowledge-to-Action AZD1208 cost cycle and phases of the Medical Research Council framework. Analysis of
this procedure informed a proposed seven-step process that may be applied by others in the development of knowledge translation tools and complex interventions.
Conclusions: The combined frameworks can be used to map the process for translating evidence into practice by addressing potential barriers, and anticipating how knowledge will be sustained and disseminated. (C) 2012 Elsevier Inc. All rights reserved.”
“Atopic dermatitis (AD) is a relapsing inflammatory skin disease with a considerable social and economic burden. Functional textiles may have antimicrobial and antipruritic properties and have been used as complementary treatment in AD. We aimed to assess their effectiveness and safety in this setting. We carried out a systematic review of three large biomedical databases.