We have reported that SSA/P was found more often in the right side of the colon of older women and shows the type II-open pit pattern in magnifying endoscopy. BRAF mutation was common in SSA/P and MSI positive cases were detected in cancerous cases
including follow-up. We retorospectively investigate advanced colorectal cancer and report assumption of SSA/P derived from advanced colorectal cancer and its characteristics. Methods: Of advanced colorectal cancer which was performed by surgical resection at our center between July 2009 and July 2013, analysis was performed on 148 cases (148 lesions) which Lenvatinib molecular weight could be analyzed by molecular biology GSK126 mouse and pathology. Age, gender, localization, tumor size, gross morphology, tissue type and genetic mutation were investigated. Results: Classification
of the target lesion is as follows; the number of male is greater than female (93 vs. 55 cases) in gender differences. Regarding age, 69 cases with <70 years old and 79 cases with ≧70 medchemexpress years old. The mean patient age was 69.1 years old. With respect to location and tumor size, there are 58 cases in the right side of colon and 90 cases in the left side of colon. With respect to tumor size, there are five cases with <20 mm, 73 cases with between 20 mm and 50 mm and 70 cases with >50 mm. The mean tumor size was
49.1 mm. By the genetic analysis, BRAF mutation, six cases (4.1%); Kras mutation, 38 cases (25.7%); no variation, 104 cases (70.2%). Regarding BRAF mutation, male, 3 cases; female, 3 cases. The mean age was 70.7 years old. Four cases were ≧70 years old and two cases were male. The mean tumor size of BRAF mutation lesion was 40.8 mm, with two cases with tumor size between 20 and 50 mm. There were no localized portions observed in three cases in the right and left side colons. Macroscopic form was type 2 in all cases. Regarding histology, well-differentiated adenocarcinoma was not observed. All of the cases were moderately differentiated + poorly differentiated adenocarcinoma or moderately differentiated adenocarcinoma histology.