The median time from patient arrival to the start of emergency bleeding control in the non-CT group was 74 (63 to 114) minutes, significantly shorter than that of 84 (67 to 121) minutes in the CT group. The 28-day mortality rate was also significantly higher in the non-CT group versus the CT group (80% vs. 18%, P <0.001).Table selleck chem 1Baseline characteristics and diagnostic data of the study populationEffect of CT on mortality by multivariate logistic regression analysisBecause significant differences existed in baseline severity of trauma between the two CT groups, multivariate logistic regression analysis was applied to adjust for possible confounders. Covariates to estimate the effect of CT in the regression model were TRISS Ps in model 1, and BE, BT and PT in model 2, as shown in Table Table2.
2. Consequently, CT was found to be an independent predictor for survival that added significant predictive power to both models (model 1: odds ratio (OR), 7.224; 95% confidential interval (CI), 1.763 to 29.601; P = 0.006 and model 2: OR, 11.745; 95% CI, 3.313 to 41.637; P <0.001).Table 2Results of multivariate logistic regression analysisEffect of CT on mortality by standard mortality ratio analysisIn the subgroup with less severe trauma (TRISS Ps ��50%), SMR showed no significant difference between observed and predicted mortality either in the CT group or the non-CT group (Figure (Figure2).2). In the subgroup with more severe trauma (TRISS Ps <50%), when comparing observed mortality with predicted mortality, results in the CT group showed observed mortality of 50% versus predicted mortality of 76.
4%. Thus, SMR showed a significant difference only in the CT group (SMR, 0.65; 95% CI, 0.41 to 0.9; P = 0.004), indicating that observed mortality was significantly lower than predicted mortality, whereas this was not the case in the non-CT group.Figure 2Outcome analysis for calculation of standardized mortality ratio (SMR) on the basis of the Trauma and Injury Severity Score (TRISS) method. All patients were divided into two groups on the basis of TRISS Ps. The gray columns represent observed mortality …In addition, in the hemodynamically unstable subgroup (SI just before CT of ��1), SMR showed a significant difference only in the CT group (SMR, 0.54; 95% CI, 0.16 to 0.91; P = 0.014) (Figure (Figure3),3), indicating that observed mortality was significantly lower than predicted mortality.
In the hemodynamically stable subgroup (SI just before CT <1), SMR showed no significant difference in the CT group.Figure 3Outcome analysis for calculation AV-951 of standardized mortality ratio (SMR) on the basis of shock index (SI) value. The patients who underwent CT scanning were divided into two groups on the basis of their SI value. The gray columns represent observed mortality …