SR-BI is an interesting receptor because HCV, whose replication cycle intersects with
lipoprotein metabolism, seems to exploit some aspects of its physiological functions, such as cholesterol transfer from high-density lipoprotein (HDL), during cell entry. SR-BI is also involved in neutralisation attenuation and therefore could be an important target for therapeutic intervention. Recent results suggest that it should be possible to identify inhibitors of the interaction of HCV with SR-BI that do not impair its important physiological properties, as discussed in this review.”
“Primary thyroid-like papillary adenocarcinomas of the nasopharynx are rare, with only a limited number of cases reported in the literature. However, it is important that pathologists and clinicians alike PLX4032 datasheet recognize this entity, as these neoplasms are amenable to surgical resection and carry an excellent prognosis. In this article, we describe the case of a thyroid-like papillary adenocarcinoma of the nasopharynx in a 19-year-old male, with emphasis on clinical findings, histologic and immunohistochemical characteristics, and prognosis. In addition, we include a review of the literature to highlight what we know to date about this rare entity. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:e25-e28)”
“Introduction: Owing to wide availability,
low cost and avoidance of ethical concerns, umbilical cord blood (UCB) provides an attractive source of stem cells for investigational GSK923295 concentration and therapeutic uses. In this study, we sought to characterize the gene expression changes as stem cells from UCB differentiate toward alveolar type II pneumocytes (ATII).
Methods: Control and Liproxstatin-1 molecular weight experimental cells were cultured in maintenance medium (mesenchymal stem cell growth medium) or differentiation medium (small airway growth medium (SAGM)), respectively, for 8 days.
Total RNA was isolated from control and experimental groups for gene expression profiling and real-time polymerase chain reaction assay.
Results: Analysis of only mixed cell lines (n = 2) with parameters including a P value of 0.01 and an intergroup gap of 2.0 yielded a set of 373 differentially expressed genes. Prominently upregulated genes included several genes associated with ATII cells and also lung cancers: ALDH3A1, VDR and CHKA. Several upregulated genes have been shown to be integral or related to ATII functioning: SGK1, HSD17B11 and LEPR. Finally, several upregulated genes appear to play a role in lung cancers, including FDXR and GP96. Downregulated genes appear to be associated with bone, muscle and central nervous system tissues as well as other widespread tissues.
Conclusions: To the best of our knowledge, this accounting of the gene expression changes associated with the differentiation of a human UCB-derived stem cell toward an ATII cell represents the first such effort. Dissecting which components of SAGM affect specific gene regulation events is warranted.”
“Objective.