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“Background Staphylococci are common commensal bacteria of the skin [1], as well as important pathogens

in foreign-body infections [2]. The gram-positive Staphylococcus (S.) find more aureus is a major human pathogen. PRN1371 mouse It is the cause of many nosocomial infections,

including life-threatening diseases such as toxic shock syndrome, sepsis and endocarditis [3]. S. aureus infections Etofibrate account for approximately 19,000 deaths per year in the United States [4]. The emergence of multi-drug resistant strains of S. aureus, such as methicillin-resistant S. aureus (MRSA), has intensified the need for new treatments [5]. The danger of untreatable staphylococcal infections highlights the importance of new anti-microbial drug discovery. It has been discovered that chronic, infected wounds are often infected with strong biofilm forming bacteria, such as S. aureus [6], and it is now thought that the presence of biofilm actively prevents the healing of these wounds [7]. Chronic wounds can arise as a result of pressure sores, venous leg ulcers, diabetic foot ulcers or combat wounds, for example. While physical debridement can assist the healing of these wounds, biofilm-focused therapeutic approaches can promote more rapid healing in a large percent of patients [7]. This biofilm-centric philosophy may represent a modern strategy to treat chronic, infected wounds in which reducing the ability of the bacteria to form biofilm is itself the critical goal. In this strategy, subsequent healing by the body or treatment with antibiotics is then more effective.