More work should be done in the future to enrich the theory of tu

More work should be done in the future to enrich the theory of tumor blood supply pattern, which may provide reasonable theoretic evidence for tumor anti-angiogenesis. In the current study, we identified that the positive rate of VM in LSCC is 21.67%, which is different from other tumors, such as inflammatory and ductal breast carcinoma (7.9%), ovarian carcinoma(36.4%), melanoma(5.3%), rhabdomyosarcoma(18.8%), and synovial sarcoma(13.6%). That is probably due to different tissue origin and judgment criteria variable across BYL719 mw labs. More investigation of a larger sample is needed to illustrate the mechanism of VM formation in different tissue. Previous research

has demonstrated VM existed in most tumors, being a functional microcirculation [24, 25], AR-13324 supplier correlated with poor clinical outcomes among tumor patients [14, 26]. The majority of studies in vitro have focused on the mechanism, until recently. However, relatively few studies have interpreted VM’s influence on a tumor’s overall biological behavior using a large sample. In addition, there still no data which describes a significant difference between VM and other patterns of blood supply. In this study, we compared the significance of clinicopathology and prognosis between VM and EDV. This retrospective study of 203

LSCC patients showed that VM is associated with lymph node metastasis, pTNM stage and histopathology grade in LSCC. While EDV correlated with tumor location, pTNM stage, T stage and distant metastasis. This indicated ifenprodil that both VM and

EDV played an important role in tumor progression. Our study showed that VM is related to local lymph node metastasis intimately, which is an important feature and a key prognostic factor of LSCC[27]. It is different from a previous study[28], which reported that patients with breast carcinomas engaged in VM and had a higher rate of distant metastasis (liver, lung, and bone), but failed to find a significant correlation with lymph node metastasis status. In our study of 203 LSCC, only 9.36% appeared to have distant metastasis, while 74.38% developed local lymph node metastasis. We deduced from this that VM in LSCC may own the specific ability to facilitate metastasis by some modality. More studies are warranted to elucidate the effects of VM which use a larger sample on local lymph node metastasis in different types of tumors. VM in tumors plays an important role in tumor aggression [5]. We also found VM is more common in the advanced stage of LSCC than in the primary stage. However, these results are different than the observations from a breast cancer study by Shirakawa et al[28], which showed that the VM group did not exhibit a more advanced pTNM stage than the non-VM group.

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