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and carried out the analysis of the literatures and drafted the manuscript. LZ and YW selleck screening library carried out the collection of the literatures. BZ helped with the statistical analysis and manuscript drafting. ZC and WZ conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Gastric cancer is one of the most frequent cancers in the world, and almost of 50% gastric cancer death occurred in China [1–3]. GS-4997 datasheet Surgery offers the only realistic chance of cure; However, many of the patients present with unresectable tumors at the time of diagnosis. Even with resection, still more than 50% of patients will relapse and eventually die of their disease [4, 5]. Therefore, non-surgical methods have attracted increasing attention. In recent years, 125I implantation has been widely used to treat prostate cancer and other tumor types because of its ability to offer high precision, little trauma, strong lethality, and fewer complications [6–9]. Most recently, Wang and colleagues applied 125I implantation to treat advanced gastric cancer and found significant improvement Interleukin-2 receptor in clinical symptoms and life quality of patients . Although the 125I seed implantation have been successfully applied in clinic, its radiobiological effect and underlying
molecular mechanism are far from fully understood. Recently, Zhuang and colleagues indicated that continuous low dose rate irradiation influenced the proliferation of cells via MAPK signal transduction. And apoptosis was the main mechanism of cell-killing effects under low dose rate 125I irradiation in CL187 cells . Besides, Ma and colleagues demonstrated that 125I irradiation significantly induced cell apoptosis and inhibited DNMT1 and DNMT3b expression at 4 Gy in pancreatic cancer cells. Thus, the irradiation-induced apoptosis and DNA hypomethylation might be two key mechanisms underlying the therapeutic effect of low energy 125I seed implantation . However, to date, the global molecular changes induced by 125I irradiation have not yet been fully understood.