It is less time consuming and economical. A statistical comparison of the quantitative determination of repaglinide shows that HPLC selleck inhibitor method as more accurate and precise than UV method. The results indicate HPLC and UV spectrotometry methods are adequate methods to quantify repaglinide in pure form and its dosage form. There was no interference by excipients in the tablets and the mobile phase is easy to prepare. Since these methods are simple, specific, rapid, precise and accurate, they may be successfully and conveniently adopted for routine quality control analysis of repaglinide in bulk and pharmaceutical dosage form. ACKNOWLEDGMENTS Authors are thankful to the Manager, USV Lab. Pvt. Ltd., Mumbai, India for providing the gift samples and also thankful to Dr. K. P.
Bhusari, Principal, Sharad Pawar College of Pharmacy, Nagpur for providing experimental facilities for this work. Footnotes Source of Support: Nil Conflict of Interest: None declared.
Telmisartan (TELM) chemically 4��-[(1, 4��-Dimethyl-2��-propyl-[2, 6��-bi-1H-benzimidazol]-1��-yl) methyl]-[1, 1��-biphenyl]-2-carboxylic acid, is a nonpeptide angiotensin-II receptor antagonist, which selectively and insurmountably inhibits angiotensin-II AT1 receptor subtype without affecting other systems involved in cardiovascular regulation [Figure 1]. Atorvastatin (ATV) calcium chemically [R-(R*, R*)]-2-(4-fluorophenyl)-��, ��, dihydroxy-5-(1-methyl ethyl)-3-phenyl-4 [(phenyl-amino)-carboxyl]-1 H-pyrrole-1-heptanoic acid calcium salt is a second generation synthetic 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase inhibitor, which decreases de novo cholesterol synthesis [Figure 2].
ATR decreases the amount of low-density lipoprotein (LDL)-cholesterol in blood, reduces blood levels of triglycerides and slightly increases levels of high-density lipoprotein (HDL)-cholesterol.[1�C3] Literature survey reveals several methods for determination of TELM and ATV individually in biological fluids and formulation like HPLC, TLC-densitometric, and derivative spectrophotometry.[4�C14] HPLC and HPTLC methods were reported for determination Carfilzomib of TELM and ATV in combination.[15,16]. Figure 1 Chemical structure of telmisartan Figure 2 Chemical structure of atorvastatin calcium However, due to lack of such equipments in many resources-limited countries and high costs of HPLC grade solvents and columns, alternative methods are needed to facilitate and increase the speed of analysis, with relatively few costs. Spectrophotometry continues to be very popular, because of its simplicity, versatility and low cost. In this paper, a successful attempt has been made to estimate two drugs simultaneously by UV spectrophotometric analysis.