In order to check the importance and specificities of PHC, a subcategory for odd delusional disorders (or even a specific category) could be useful, not only for its clinical value, which was considered as obvious in France nearly a century ago, but also for the important problem of the phenotype boundaries

in schizophrenia, for example, in genetic analyses. The data provided herein may illustrate the fact that taking into consideration the PHC phenotype could shed light on the clinical approach to the concept of anticipation in schizophrenia.
There is considerable Inhibitors,research,lifescience,medical folk wisdom about cognitive aging in our culture. One familiar but disheartening proverb suggests that “You can’t teach an old dog new tricks,” while a more optimistic one states that “Older is wiser.” A Inhibitors,research,lifescience,medical third proverb, “Use

it or lose it” seems to be a restatement of the American dream, as it implies that anyone can earn or maintain their “cognitive fortune” into late adulthood if only one works hard enough. Perhaps this third proverb explains the paradox represented in the first two. These proverbs encompass issues that have been of considerable Inhibitors,research,lifescience,medical concern to cognitive aging researchers for the past 25 years. Do older adults learn new information as effectively as the young? Does knowledge (a basis for wisdom) increase with age? What is the role of experience and cognitive “exercise” in protecting the cognitive system from age effects? Can using the mind actually protect it from cognitive loss or compensate for cognitive losses already sustained, much like exercise and diet can prevent or repair heart disease? Behavioral scientists have learned Inhibitors,research,lifescience,medical a great deal about these issues, but their knowledge is still incomplete. Recently, the ability to look into the mind with functional imaging techniques has provided scientists with new tools to address these questions. The goal Inhibitors,research,lifescience,medical of the present paper is to provide one view of the relationship between behavioral findings about cognitive aging and their neural underpinnings, Metformin mouse drawing

primarily from structural and functional data about the aging brain. Megestrol Acetate We first briefly review some of the cognitive mechanisms that have been isolated by behavioral studies as central to understanding agerelated cognitive decline and follow this with an overview of new findings about the aging brain from the structural and functional imaging literature. We also consider some methodological issues associated with imaging that constrain our ability to integrate brain and behavioral data. We then provide integration between the behavioral and neural findings, discussing findings where the brain and behavioral data are consistent, and other areas where they are inconsistent or simply unconnected.