In 55 cases (30 male, 25 female) and in 56 cases (35 male, 21 female) there were no right PCoA and left PCoA, respectively. In 71 cases (47 male, 24 female) and in 74 cases (44 Ceritinib solubility male, 30 female) there were fine calibrated right PCoAs and left PCoAs, respectively. In all of the cases (8 right, 6 left) that had PCAs with fetal origin, there were well-developed PCoAs (Figure 6). There was no statistically significant difference between genders according to the presence of the PCA with fetal origin in CT or MR angiographies. Additionally, there was no statistically significant difference according to the absence of the PCoAs (P > 0.05, chi-square test). Figure 6Axial MIP (a) and posteroanterior view VR (b) CT angiography images show a right PCA with fetal origin in a 42-year-old man.

The P1 segment of the right PCA is agenetic, and there is a well-developed right PCoA that supplies the P2 and distal segments … In our study group (n = 135) only 47 cases (34.8%) had well-known normal vertebrobasilar system anatomy. In the rest of the cases (65.2%), there was at least one anatomic variation. The most common variation was isolated agenesis of right PICA that was seen in 17.8% of the cases (24/135). The second one was isolated agenesis of left PICA that was seen in 11.1% of the cases (15/135). The variations and their frequencies that were encountered in our study group are presented in Table 2. There was at least one variation in 60.6% and 65.6% of the cases in CT and MR angiographies, respectively. There was no statistically significant difference between the frequencies of the variations in CT and MR angiography techniques (P = 0.

643, chi-square test) or in gender groups (P = 0.282, chi-square test). Table 2Variations of the vertebrobasilar circulation. In our study group, we demonstrated fenestration of the basilar artery in 2 cases, fenestration of the left PCA in 1 case, dolichoectasia of the basilar artery in 14 cases, and vertebral/basilar artery indentation to the Bulbus/Pons in 16 cases. 4. DiscussionVertebrobasilar system supplies blood to the cerebellum and critical parts of the brainstem. As seen in any vasculature, variations of the major branches of the vertebrobasilar system are usually encountered.

The most common variations reported in the literature are agenesis of AICA or PICA, AICA originating from PICA, GSK-3 PICA originating from internal carotid artery, persistence of a primitive communicating vessel (presegmental artery) between anterior and posterior circulation, and PICA originating from posterior meningeal artery [3]. In our study group (n = 135) only in 47 cases (34.8%) there were well-known normal vertebrobasilar system anatomy. In the rest of the cases (65.2%), there was at least one anatomic variation. The most common variation was isolated agenesis of the right PICA (17.