Finally, the methods used in this study serve only to describe st

Finally, the methods used in this study serve only to describe statistical associations between variables, which are not necessarily proof of causation. 5 Conclusion

A significant proportion (13.44 %) of NICM patients who experienced an improvement in LVEF with BB therapy in the first year had a subsequent decline. Race, NYHA class, baseline LVEF, and age are important predictors of post-response LVEF decline. An underlying genetic difference may explain differences in LVEF response to BB therapy observed in this study. Future studies should evaluate genetic polymorphisms affecting beta-adrenoceptor function in patients with NICM. Acknowledgments Dr. Kelesidis contributed to collecting the data, quantitation of echocardiograms, data analysis, and writing and editing the manuscript. Dr. Hourani contributed to collecting the data, writing and editing the manuscript. Dr. Varughese selleckchem contributed to collecting the data, writing and editing the manuscript. Dr. Zolty contributed to conceiving the study, quantitation of echocardiograms, data analysis, and writing and editing the manuscript. Disclosure statement Funding for this project was provided by the Congestive Heart Failure Division LY3039478 purchase Fund, Montefiore Medical Center. These data were presented in part at the 13th Annual Scientific meeting of the Heart Failure Society of America, September 2009, Boston, MA, USA. None of the authors has a financial relationship with a commercial entity that

has an interest in the subject of the presented manuscript or other conflicts of interest to disclose. Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial learn more License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. References 1. Gillum RF. The epidemiology of cardiovascular disease in black Americans. N Engl J Med. 1996;335:1597–9.PubMedCrossRef 2. Dries DL, Exner DV, Gersh Glutamate dehydrogenase BJ, Cooper HA, Carson PE, Domanski MJ.

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