Estradiol and progesterone were administered separately and in a double-blind, crossover design. We found that when the endogenous ovarian hormones, estrogen and progesterone, of young women were pharmacologically ablated, the neurophysiological response to PI3K inhibitor performing

a frontal lobe task (the Wisconsin Card Sorting Test [WCS]) was attenuated, and the typically seen frontal lobe activation virtually disappeared. When either estrogen or progesterone was pharmacologically “added back” to the hypogonadism produced by leuprolide acetate, the activation pattern in response to the cognitive challenge of the WCS normalized and the prefrontal activation was reestablished (Figure Inhibitors,research,lifescience,medical 3.). These data directly demonstrate that gonadal steroid hormones affect cognitively related neural activity. They also illustrate

how functional neuroimaging can provide a framework for understanding the neurobiological mechanisms underlying gender-related Inhibitors,research,lifescience,medical brain features as well as hormone-related neuropsychiatrie and neuropsychological disorders. Figure 3 Regional cerebral blood flow (rCBF) Inhibitors,research,lifescience,medical group average activation maps for 11 women during three different hormonal states. Top: Activation (red voxels) during the Wisconsin Card Sorting (WCS) test; the arrow shows that the characteristic prefrontal activation …
Despite the devastating impact that mood disorders have on the lives of millions worldwide, Inhibitors,research,lifescience,medical there is still a dearth of knowledge concerning their underlying etiology and pathophysiology. The brain systems

that have heretofore received the greatest attention in ncurobiological studies of major depressive disorder (MDD) are the monoaminergic neurotransmitter systems, which are extensively distributed throughout the network of limbic, striatal, and prefrontal cortical neuronal circuits thought to support the behavioral and visceral manifestations Inhibitors,research,lifescience,medical of mood disorders.1,2 The treatment of depression was revolutionized about a half -century ago with the introduction of two classes of agents that were discovered – entirely by serendipity – to be effective antidepressants: the tricyclic antidepressants (monoamine Cell press reuptake inhibitors) and the monoamine oxidase inhibitors. The discovery of the acute protein target of the antidepressant medication led to the development of numerous second-generation medications (eg, serotonin-selective reuptake inhibitors [SSRIs] and norepinephrine-selective reuptake inhibitors), which are widely used today. Thus, clinical studies over the past 40 years have attempted to uncover the specific defects in these neurotransmitter systems in mood disorders by utilizing a variety of biochemical and neuroendocrine strategies.