ESD for residual/locally recurrent lesions has the potential ability to yield high-quality histopathological specimens, facilitating and optimizing further management decisions. ESD for epithelial colorectal tumors will progress further as techniques and devices are improved. We can expect ESD to be safely performed for residual/locally recurrent lesions in the near future. In conclusion, ESD may be a curative and efficacious therapy option for residual/locally recurrent lesions after endoscopic therapy. This approach PF-02341066 research buy should help to avoid surgical resection and frequent diagnostic examinations in many patients. “
“Background and Aim:  Endoscopic forceps biopsy (EFB) as the primary histological diagnosis of gastric

epithelial neoplasia (GEN) is debated in the era of endoscopic resection (ER). Our aim was to investigate the diagnostic reliability of EFB in patients with GEN compared with ER specimens as the reference standard for the final diagnosis in a large consecutive series. Methods:  This was a cross-sectional retrospective

study at a tertiary-referral Selleckchem ZD1839 center. A total of 354 consecutive patients with 397 GENs underwent ER (endoscopic mucosal resection or endoscopic submucosal dissection). Discrepancy rates between the histological results from EFB and ER specimens were assessed. Discrepancies that could affect patient outcome or clinical care were considered major. Results:  The overall histological discrepancy rate between EFB and ER specimens was 44.5% (95% confidence interval [CI], 39.7–49.5%) among the enrolled patients. The overall discrepancy rate was significantly higher in the intraepithelial neoplasia (IEN) group than in the carcinoma group (49.8% vs 25.6%, P < 0.001). The major discrepancy rate was also

significantly higher in the IEN group than in the carcinoma group (36.6% vs 7.0%, P < 0.001). In subgroup analysis of the IEN group, a major histological discrepancy rate of 33.6% (70/208) for low-grade and 42.7% (44/103) for high-grade IEN was found, respectively. Conclusions:  Endoscopic forceps biopsy was insufficient for a definitive diagnosis and therapeutic planning in patients with GEN. ER should 上海皓元 be considered as not only definitive treatment but also a procedure for a precise histological diagnosis for lesions initially assessed as GEN by forceps biopsy specimens. “
“Background and Aims:  The pathogenesis of enteropathy induced by non-steroidal anti-inflammatory drugs (NSAIDs) is still unclear, and there are no established treatments. Interleukin-17A (IL-17A) is a pro-inflammatory cytokine that has been associated with the development of chronic inflammatory diseases, including autoimmune diseases. To define the role of IL-17A in small intestinal injury and inflammation, we studied the effects of indomethacin administration in mice with targeted deletions of the IL-17A gene. Methods:  Male C57BL/6 (wild-type) and homozygous IL-17A-/- C57BL/6 mice were subjected to this study.