Cardiac ouput (LiDCO technique) was measured and arterial and venous bloods taken every 15 minutes. Cardiac index (CI), systemic vascular resistance (SVR), arterial and venous oxygen content (CaO(2), CvO(2)) and oxygen delivery (circle dot O(2)) were calculated. Analysis of variance with separate models for each CRI rate was used to detect differences between values obtained at the end of the CRI and their respective baseline values. A mixed model with these differences as response

variable, pony as random effect and treatment and period as fixed effects was applied to find differences between the two CRIs (alpha = 0.05 for all analyses).\n\nResults\n\nHeart LY3039478 supplier rate (HR), CI, CaO(2), CvO(2) and circle dot O(2) decreased significantly, while significant increases were found in SVR, systolic

arterial pressure and right atrial pressure with both infusion rates. No differences were found between the two dexmedetomidine CRI rates.\n\nConclusions and clinical relevance\n\nAlthough significant, cardiopulmonary effects of the dexmedetomidine CRIs in isoflurane anaesthetized ponies were small, without differences between the two dose rates.”
“Objective\n\nTo describe obstetric intervention for extremely preterm births in ten European regions and assess its impact on mortality and short term morbidity.\n\nDesign\n\nProspective observational cohort Fer-1 study.\n\nSetting\n\nTen regions from nine countries participating in the ‘Models of Organising Access to Intensive Care for Very Preterm Babies in Europe’ (MOSAIC) project.\n\nPopulation\n\nAll births from 22 to 29 weeks of gestation (n = 4146) in 2003, excluding terminations of pregnancy.\n\nMethods\n\nComparison of three obstetric interventions (antenatal corticosteroids, antenatal transfer and caesarean section for fetal indication) rates at 22-23, 24-25 and 26-27 weeks to that at 28-29 weeks and the association of the level of intervention with pregnancy outcome.\n\nMain outcome measures\n\nUse of antenatal corticosteroids, antenatal transfer and caesarean section by two-week gestational age groups as well as a composite score of these three interventions. Outcomes included

stillbirth, in-hospital mortality and intraventricular haemorrhage (IVH) grades III and IV and/or periventricular leucomalacia (PVL) and bronchopulmonary MLN2238 dysplasia (BPD).\n\nResults\n\nThere were large differences between regions in interventions for births at 22-23 and 24-25 weeks. Differences were most pronounced at 24-25 weeks; in some regions these babies received the same care as babies of 28-29 weeks, whereas elsewhere levels of intervention were distinctly lower. Before 26 weeks and especially at 24-25 weeks, there was an association between the composite intervention score and mortality. No association was observed at 26-27 weeks. For survivors at 24-25 weeks, the intervention score was associated with higher rates of BPD, but not with IVH or PVL.