Associations were investigated in a well-characterized sample of adults with bipolar disorder, major depressive disorder, or healthy controls. Candidate polymorphisms were expected to show only modest associations with

mood disorder symptoms and diagnoses. However, genetic variation was expected to be significantly associated with individual differences in cognitive processing (global ability, impulsivity, memory) and fronto-limbic volumes. Fronto-limbic volumes Inhibitors,research,lifescience,medical were expected to mediate the relationships between genetic variation and cognitive vulnerability to mood disorder. Materials and Methods Participants The present sample represents a subgroup of individuals accrued through multiple diagnostic clinics and recruited into overlapping NIMH-funded research studies evaluating neuroimaging findings in adults with mood disorders at the University of Texas Health Science Center at San Antonio. In these studies, adult participants Inhibitors,research,lifescience,medical were recruited using advertisements broadcast on the radio and flyers placed

Inhibitors,research,lifescience,medical in the community and at hospitals and clinics in the South Texas Medical Center area. Age, gender, handedness, and race/ethnicity (coded as white/non-Hispanic and other race/ethnicity) were obtained via IAP inhibitor library clinical interview. Participants received a physical examination and laboratory tests to rule out physical illnesses and substance use. Any participant with endocrinological disease, head trauma, neurological disease, family history of hereditary Inhibitors,research,lifescience,medical neurological disorder, or a

medical condition such as hypertension, diabetes, active liver disease, kidney problems, respiratory problems, or current alcohol /drug abuse dependence was excluded. Left handed and ambidextrous participants were excluded from this sample to reduce heterogeneity of neuroimaging. The Institutional Review Board of the University of the Texas Health Science Center at Houston and Baylor College of Medicine approved this study. Written informed Inhibitors,research,lifescience,medical consent was obtained from all the participants after a complete Ketanserin description of the study was provided. Procedures Diagnostic and symptom assessment Participants were evaluated for DSM-IV-TR Axis I disorders using the Structured Clinical Interview for DSM-IV (SCID) Axis I disorders, research version, patient edition (First et al. 2002). A senior psychiatrist (JCS) reviewed all clinical information, including history of medical and neurological conditions, and confirmed that all subjects met DSM-IV-TR diagnostic criteria for bipolar disorder (BD) or for Major Depressive Disorder. Clinical symptom ratings were completed using the Hamilton Rating Scale for Depression (HAM-D; Hamilton 1960) and the Young Mania Rating Scale (YMRS; Young et al. 1978).