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between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 1994, 71:219–225.PubMed 49. Terasaki M, Runft L, Hand AR: Changes in organization of the endoplasmic reticulum during Xenopus oocyte maturation and activation. Mol Biol Cell 2001, 12:1103–1116.PubMed Authors’ contributions MZ performed the experiments. EK and MZ both designed the study, drafted and wrote the manuscript. Both authors have read and approved the final text. Competing interests The authors declare Ureohydrolase that they have no competing interests.”
“Background Symbiotic communities of eukaryotic organisms are known to influence host developmental programs [1] and also to shape immune response against pathogens [2]. Interestingly, some genes/pathways (e.g. programmed cell death) have a pleiotropic role in immunity and development, and could play a major role in the maintenance of a specific bacterial

community. For instance, the homeobox gene Caudal is involved in the formation of the antero-posterior body axis of Drosophila, but also in the regulation of the commensal gut microbiota [3]. In the squid-vibrio association, it has recently been shown that the regulation of a peptidoglycan recognition protein (PGRP), classically involved in innate immunity, plays a role in the activation of the apoptotic process initiating the morphogenetic changes of the symbiont-harboring organ [4]. The generality of the interplay between immunity and development during symbiosis is currently unknown. Wolbachia (Anaplasmataceae) is among the most abundant intracellular bacteria. It infects both arthropods and nematodes, and is known to be a master manipulator of host biology [5].