955, 8, 9.174, respectively, indicative of a very sick cohort with high risk of mortality. Medical therapy consisted of standard medical care for advanced liver disease and a variety of AH therapies by referring providers and hepatologists, with about one-third receiving glucocorti-coid-based therapies, but 51% were ineligible due to severe illness. The overall mortality or LT

rates at day 30, 90 and 180 were 39%, 54% and 56%, respectively. There were no significant differences in the areas under the receiver operating characteristics curve (AUROC) relative to 30-day/90-day/180-day mortality/LT: MELD 0.80/0.71/0.71, Lille 0.64/0.68/0.69, GAHS 0.69/0.67/0.68, ABIC 0.71/0.69/0.69, respectively. Among 14 patients with a >25% fall in bilirubin, clinical readiness for discharge before 1 week and mostly without AH therapies (79%), the survival rate was 100% at 6 months. Conclusions: MELD, Lille, GAHS and ABIC scores are equally valid in our independent, prospectively Roxadustat purchase evaluated

cohort of severe AH. We also identified a subgroup of severe AH patients with 100% survival at 180 days: those with a >25% fall in bilirubin and clinical readiness for discharge before 1 week despite lack of specific AH therapies. Disclosures: Scott L. Friedman – Advisory Committees or Review Panels: Pfizer Pharmaceutical, Sanofi-Aventis; Consulting: Conatus Pharm, Exalenz, Genenetch, Glaxo Smith Kline, Hoffman-La Roche, Intercept Pharma, Isis Pharmaceuticals, Melior Discovery, Nitto Denko Corp., Debio Pharm, Synageva, Gilead Pharm., Ironwood Pharma, Alnylam Pharm, Tokai Pharmaceuticals, Bristol PF-02341066 mw Myers Squibb, Takeda Pharmaceuticals,

Nimbus Discovery, Bristol Myers Squibb, Intermune, Astra Zen-eca, Abbvie, Intermune; Grant/Research Support: Galectin Therapeutics, Tobira Pharm, Vaccinex Therapeutics, Tobira; Stock 上海皓元 Shareholder: Angion Biomedica The following people have nothing to disclose: Gene Y. Im, Aparna Goel, Thomas D. Schiano Purpose: Zinc deficiency occurs in human subjects with alcoholic cirrhosis (AC), and zinc supplementation attenuates liver injury/inflammation in murine models of alcoholic liver disease. The aim of this interim analysis of the NIH-funded ZAC clinical trial is to determine if zinc sulfate therapy improves serologic biomarkers of liver injury/inflammation in AC. Methods: 22 Subjects with Child-Pugh class A-B alcoholic cirrhosis were randomized to placebo or zinc sulfate 220 mg daily in the single center, double-blind, placebo-controlled ZAC clinical trial. The 2 year study is ongoing. Here, baseline and 3 month biomarker data are presented. 10 non-drinking, age-matched, healthy controls (HC) were recruited as controls for baseline biomarker comparison. Serum adipocytokines (including IL-1 β, IL-6, IL-8, IL-10, TNFα, and insulin) and whole blood ex vivo unstimulated, lipopolysacharide-stimulated (LPS), and phyto-hemagglutinin-stimulated (PHA) cytokine production were measured by Luminex.