8%) validity, and scaling success (86.8%) rates. Cronbach’s alpha coefficients exceeded 0.70 for all scales, except problems with sexuality (0.60) and problems with senses (0.61), which also evidenced a lower scaling success rate (50%). Confirmation of construct validity included satisfactory results for inter-scale correlations and GDC-0068 cost known-groups comparisons for most scales; most correlations were statistically significant (p<0.01), with conceptually related scales showing relatively higher correlation. Most scale scores were able to discriminate clearly between pre- and current treatment

patients.

Conclusions: Results of the study provide strong support for the psychometric robustness of the ‘Sinhala’ version of the

QLQ-H&N35. It may be advisable to interpret the two items assessing sensory problems separately, and to elicit information on sexuality from only those who are sexually active. Copyright (C) 2009 John Wiley & Sons, Ltd.”
“Optimal strategies to prevent progression towards overt diabetes in women with recent AG-014699 molecular weight gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n = 13) versus Supported Care (individualised Selleckchem SYN-117 exercise program with regular telephone support; n = 15). Baseline characteristics (Mean +/- SD) were: Age 33 +/- 4 years; Weight 80 +/- 20 kg and Body Mass Index (BMI) 30.0 +/- 9.7 kg/m(2). The primary outcome, planned physical activity Median (Range), increased by 60 (0-540) mins/week in the SC group versus 0 (0-580) mins/week

in the UC group (P = 0.234). Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.”
“Histology is an important outcome variable in basic science and pre-clinical studies regarding intervertebral disc degeneration (IVD). Nevertheless, an adequately validated histological classification for IVD degeneration is still lacking and the existing classifications are difficult to use for inexperienced observers.

Objective: Therefore the aim of this study was to develop and to validate a new histological classification for IVD degeneration. Moreover, the new classification was compared to the frequently used nonvalidated classification.

Methods: The new classification was applied to human IVD sections.