7%) thrived without clinical complications for 14 days. Autopsy revealed all closures of perforation of pharyngeal diverticulum were

secure without any sign of leakage. Conclusion: The mediastinum can be successfully accessed through a trans-pharyngeal diverticulum acess using flexible endoscope. Connective tissue tunnels are safe, and a promising concept for targeted mediastinal exploration. With refinement in technology, this approach may be useful for a variety of mediastinal surgeries. Key Word(s): 1. endoscopic surgery; Table 1 Detailed operation time of each key procedures Procedures Mean time (min) Esophageal dissection 11.7 ± 3.2 Pyriform sinus access site making 12.3 ± 2.8 Mediastinal exploration and taking Inhibitor Library out FB 10.4 ± 5.8 Closure of esophageal incision 7.3 ± 3.8 Closure of pyriform sinus access site 6.2 ± 4.0 Presenting Author: MUNA PALIKHE Additional Authors: JIA YUAN, HUI XUE Corresponding Author: HUI XUE Affiliations: Xi’an Jiao Tong University Objective: The objective of this study is to analyze the changes Ganetespib price in portal hemodynamics that occurs in

portal hypertension before and after transjugular intrahepatic portosystemic shunt (TIPS), to investigate the relationship between these changes and portal pressure (PP) and to determine the significance of sonographic parameters in measuring PP. Methods: Ultrasonography

of the portal and splenic veins and direct measurement of the PP were performed in 92 patients before and after TIPS. The differences observed in the portal and splenic vein diameters, the blood flow velocity in the portal and splenic veins and the PP were measured, PRKACG and the correlations between PP and the other parameters were assessed using the SPSS 13 software. P < 0.05 was considered statistically significant. Results: We observed a significant decrease in the PP and the diameters of the portal and splenic veins compared to preoperative conditions (p < 0.001). The velocity of blood flow in the portal and splenic veins was significantly increased after TIPS (p < 0.001). The PP correlated with the diameter and velocity of blood flow in portal (r = 0.46, p = 0.020; r = 0.47, p = 0.017) and splenic vein (r = 0.57, p = 0.003; r = 0.33, p = 0.003) only in Child’s A and was absent in Child’s B cirrhosis patients. Conclusion: The PP is influenced by the complex interaction between intrahepatic vascular resistance, collaterals and the amount of portal blood flow, which varies considerably between individuals. Once a certain pressure threshold is reached, collaterals form, and the correlation between the ultrasonographic parameters and PP becomes limited. Key Word(s): 1. portal hypertension; 2. portal vein; 3. TIPS; 4.