Although minor bleeding is not essential for vitality, it is associated with poor visual field, delayed operation time, and sometimes, unexpected perforation. Understanding the anatomy of vessels, techniques to reach the deep submucosal layer, frequent precoagulation (which is tediously slow, but like the tortoise, an eventual winner), and proper hemostasis techniques are imperative to avoid unnecessary intraoperative bleeding.8 Prior to the determining the suitability of gastric lesions for ESD, the depth of invasion is an HSP targets important factor. Endoscopic ultrasonography (EUS) is a useful diagnostic modality in various parts of the gastrointestinal tract and neighboring

organs, and the most accurate method for T and N staging of upper gastrointestinal malignancy. Numerous studies have demonstrated the superiority of EUS over other modalities.9 Recently, clinicians have made great efforts to make diagnoses more precisely and to minimize ‘blind Selleckchem Crizotinib spots’. Hwang et al. demonstrated that the overall accuracy of EUS for T and N staging was 62% and 66%, respectively.10 In their study, EUS showed poor accuracy (31%) for the ulcerative type of EGC. However, another study reported usefulness in the differential diagnosis between benign and malignant gastric ulcers. Thus, Zhang et al. reported that the sensitivity

of EUS was 84%, the specificity was 63%, and the accuracy was 72% for the diagnosis of malignant ulcers.11 In this issue of the Journal of Gastroenterology and Hepatology, Kuroki et al. introduces EUS to the field of ESD.12 They performed EUS before ESD and evaluated the submucosal vascular structures using objective and reproducible criteria that included an abundance

of vasculature and large-diameter vessels. The outcomes Phosphoglycerate kinase of intraoperative bleeding, which were hardly expected, as they mentioned, were assessed by a median fall in hemoglobin, procedure time, the use of clips, and the restarting of food on the postoperative day. The patients with rich submucosal vascularity showed a higher hemoglobin reduction rate (5.8% vs 3.5%), longer procedure time (151 min vs 100 min), and a greater use of the clip (79% vs 32%). A multivariate analysis revealed that submucosal invasion and the use of the clip were independent factors. The authors concluded that identification of the submucosal vascular structure by EUS might help predict the risk of intraoperative bleeding and the safety of ESD. One logistic issue is the subjectivity of diagnostic criteria of EUS on the submucosal vascular structure. The authors stated that the use of color Doppler might be beneficial to confirm structures as vessels. The development of a mini probe with color Doppler would be useful for the differential diagnosis of lesions with small caliber. With this device, we anticipate concurrent EUS with color Doppler during ESD and a prediction of an abundance of submucosal vascularity.