Of all 524 participants, 55.0% were female. The median age was 39 (IQR, 27–50 years) for males and 34 (IQR, 26.5-45.5) for females. For both males and females, most participants were white,

non-Hispanic, had private health insurance, had never been Dabrafenib in vitro married, and had 12 years or more of formal education. Seventy-two percent of participants reported having been tested for HIV (76.4% of women, 66.5% of men). The majority of participants in this study Inhibitors,research,lifescience,medical had been tested for HIV more than five years ago, had never donated blood, and had been tested for HIV but not as part of a blood donation. Table 1 Participant demographic characteristics and HIV screening history Participant alcohol misuse, sexual risk for HIV Table 2 depicts participant alcohol misuse and sexual risk for HIV by sex. Approximately 75% of participants reported drinking alcohol within the past 30 days. Table 2 Participant

alcohol misuse, HIV risk and the intersection of HIV risk and alcohol misuse Thirty-three percent of males Inhibitors,research,lifescience,medical and 16.3% of females reported spending 75 – 100% days of the month drinking alcohol. The majority Inhibitors,research,lifescience,medical of participants fell within the low-risk drinking level based on AUDIT scores; however, 74.5% of males and 59.6% of females reported binging, and 26.1% of both females and males would be classified as drinking at hazardous levels. The majority of participant’s log HIV sexual risk scores fell within the first tertile level. The majority of participants, 86.1% of females and 68.2% of males, reported having only a main partner. Among drinkers, 88.6% of females and 79.8% of males reported having unprotected sex, and among non-drinkers, 80.0% of females and 80.9% males reported having unprotected sex in the past Inhibitors,research,lifescience,medical 12 months. Approximately 36.2% of males and 25.1% of females reported having sex while intoxicated, 15.4% of males and 12.3% of females regretted ever having had sex while intoxicated and 6.4% of males and 5.0% of females Inhibitors,research,lifescience,medical were unsure if they had sex while

intoxicated in the past 12 months. Relationship of sexual risk for HIV to alcohol misuse In Table 3, results of multivariable logistic regression analyses demonstrate, for both males and females, drinking status (whether participants drink or not), was strongly associated with an increase in sexual risk for HIV. For female drinkers, a greater percentage of days spent drinking and binging, reaching hazardous and harmful AUDIT levels Rolziracetam and binging status were associated with increased sexual risk for HIV among females. For male drinkers, a higher percentage of days spent drinking and hazardous and dependent AUDIT levels were associated with increasing sexual risk for HIV. Table 3 Multivariable logistic regression analyses comparing log of HIV sexual risk score and alcohol misuse, and HIV screening uptake and alcohol misuse HIV screening uptake As shown in Table 3, multivariable logistic regression was performed to assess the relationship between HIV screening uptake and alcohol misuse.