The three studies, which were mainly designed for examining the efficacy outcomes of prolonging neoadjuvant-surgery interval, also found

similar rates of blood loss, postoperative morbidity, and postoperative complications with longer intervals when TAE684 cost compared to shorter intervals, although a slightly higher rate of anastomotic complications was observed in the study by Moore et al. (6). Unlike the findings of Tran et al., Moore and Tulchinsky failed to find a difference in terms of duration of operation Inhibitors,research,lifescience,medical and hospital stay (6,8). In this study, overall rate of postoperative complications was slightly higher in the patients that received surgery after a short delay. However, rates of individual postoperative complications, i.e., deep venous thrombosis, Fournier gangrene, and pneumonia, were similar. Although current evidence suggest that delaying the operation seems safe in terms of intra- and postoperative complications, there is still concern that the tumor might progress or metastasize

during the prolonged interval between neoadjuvant Inhibitors,research,lifescience,medical treatment and surgery, which was supported by the increased number of patients with ‘tumor upstaging’ in patients that received delayed surgery (7). Conclusions Inhibitors,research,lifescience,medical Findings of the present study do not support the intentional prolongation of the chemoradiotherapy-surgery interval in an effort to improve pathological response to radiochemotherapy, local disease control or survival; although prolonging the interval seems safe based on evidence from Inhibitors,research,lifescience,medical relatively low number of patients. Surgical margin positivity and quality of surgical

performance seem to be more important. Acknowledgements This study has been presented at the general poster session of American Society of Clinical Oncology Annual Meeting, in Orlando, FL, May 29- June 2, 2009 (Abstract No, 4131). Disclosure: The authors declare Inhibitors,research,lifescience,medical no conflict of interest.
Familial adenomatous polyposis (FAP) is characterized by the development of copious adenomatous polyps throughout the gastrointestinal (GI) tract, namely the colon and rectum. The first of these polyps usually present in adolescence but the disease is progressive, with both increased Ketanserin number of polyps and malignant transformation with advancing age. Up to 80% of patients have extra colonic polyps, usually involving the upper GI tract including the stomach and duodenum. The inherent concern of course is the guaranteed development of malignancy arising from the APC germline mutation located on chromosome 5q. Cancer usually develops at a mean age of 35 years, as such, prophylactic colectomy with or without a proctectomy is considered standard of care. Extra-colonic polyps are usually benign in nature, although frequent surveys via endoscopy and pathologic confirmation via biopsy are required. Unless malignancy is detected, surgical intervention for these upper GI polyps is unnecessary.